Division of Developmental Psychobiology - NYSPI @ Columbia University
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FACULTY
NIMH TRAINING GRANT

The Long Term Effects of Early Experience

 

 

 

Michael M. Myers, PhD, Director
Phone 543 5697, Room 4911C

Lab members and Collaborators:
Andrea Tu, BA; Catherine Monk, PhD; David Brown, MD; Harry Shair, PhD; Jay Gingrich, MD, PhD; Morris Cohen, MD; Myron Hofer, MD; Peter Graham, BA; Raymond Stark, MD; Richard Sloan, PhD; Shenequa McLoed, BA; Susan Brunelli, PhD; William Fifer, PhD

 

A central tenet of Developmental Psychobiology is that experiences of early life have effects lasting into adulthood. These effects can lead to altered responses to stress, increased or decreased risk of cardiovascular disease, and the shaping of emotional states. The search for mechanisms that underlie the transduction of early experience is one focus of work in our department. Animal studies conducted in this laboratory have shown that certain adult characteristics can be influenced by specific types of mother/infant behavioral interactions associated with feeding in infancy. In collaboration with researchers at Newark Beth Israel Hospital , we are now pursuing the question of how key aspects of the pre- and postnatal environments may influence the expression of these important interactions in human infants. Most recently, we have initiated a series of animal studies to study the long-term effects of pre- and postnatal nutrition on metabolic, cardiovascular and neurobehavioral traits.


Selected Publications:

Myers MM, Gomez-Gribben E, Smith KS , Tseng A, Fifer WP. Developmental changes in infant heart rate responses to head-up tilting. (2006) Acta Paediatr. 95: 77-81.

Myers MM, Shair HN, Cohen M. (2005) Blood pressure responses to feeding in infancy: Spin-offs of serendipity. Dev Psychobiol. 47: 268-77.

Fifer WP, Myers MM, Sahni R, Ohira-Kist K, Kashyap S, Stark RI, Schulze KF. (2005) Interactions between sleeping position and feeding on cardiorespiratory activity in preterm infants. Dev Psychobiol. 47: 288-96.

Kinney HC, Myers MM, Belliveau RA, Randall LL, Trachtenberg FL, Fingers ST, Youngman M, Habbe D, Fifer WP. (2005) Subtle autonomic and respiratory dysfunction in sudden infant death syndrome associated with serotonergic brainstem abnormalities: a case report. J Neuropathol Exp Neurol. 64: 689-94.

Quigley KS , Myers MM, Shair HN. (2005) Development of the baroreflex in the young rat. Auton Neurosci. 31: 26-32.

Sahni R, Schulze KF, Kashyap S, Ohira-Kist K, Fifer WP, Myers MM. (2005) Sleeping position and electrocortical activity in low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 90(4): F311-5.

Grieve PG, Myers MM, Stark RI , Housman S, Fifer WP. (2005) Topographic localization of electrocortical activation in newborn and two- to four-month-old infants in response to head-up tilting. Acta Paediatr. 94: 1756-63.

Muller JM, Brunelli SA, Moore H, Myers MM, Shair HN. (2005) Maternally modulated infant separation responses are regulated by D2-family dopamine receptors. Behav Neurosci. 119: 1384-8.

Myers MM, Shair HN, Cohen M. (2005) Blood pressure responses to feeding in infancy: spin-offs of serendipity. Dev Psychobiol. 47: 268-77.

Fifer WP, Myers MM, Sahni R, Ohira-Kist K, Kashyap S, Stark RI, Schulze KF. (2005) Interactions between sleeping position and feeding on cardiorespiratory activity in preterm infants. Dev Psychobiol. 47: 288-96.

Schechter DS, Coots T, Zeanah CH, Davies M, Coates SW, Trabka KA, Marshall RD, Liebowitz MR, Myers MM. (2005) Maternal mental representations of the child in an inner-city clinical sample: violence-related posttraumatic stress and reflective functioning. Attach Hum Dev. 7: 313-31.

Myers MM, Ali N, Weller A, Brunelli SA, Tu AY, Hofer MA, Shair HN. (2004) Brief maternal interaction increases number, amplitude, and bout size of isolation-induced ultrasonic vocalizations in infant rats. J Comp Psych, 118: 95-102

Monk C, Sloan RP, Myers MM, Ellman L, Werner E, Jeon J, Tager F, Fifer WP. (2004) Fetal heart rate reactivity differs by women's psychiatric status: an early marker for developmental risk? J Am Acad Child Adolesc Psychiatry, 43: 283-90.